Acne can be very embarrassing at all ages. There are certain things that you can do that will prevent your skin to suddenly erupt acne. If a certain regimen is followed acne can surely be prevented.
Exercise:
Keeping yourself fit and trim can help you fight acne. The stress levels are reduced to a large extent and this stops the occurrence of depression and low self esteem. These factors contribute to prevent acne. But remember always to properly time out your regimen, put on comfortable clothing and use proper sports gear and equipment. Tight fitting garments made of nylon and lycra are extremely unsuitable if you are prone to the acne menace. Synthetic clothes confine not only the body heat but the moisture as well. This leads to rapid multiplication of bacteria leading to acne growth. Cotton clothes, loosely fitted are the best because natural fibers allow air to freely circulate and your skin gets more air. When your workout is complete remember to wear fresh clothes after having a good bath. Also remember to keep your sports equipment and clothes clean and dry. Unclean headgear can lead to forehead acne and you need to prevent it at all costs.
Diet:
You should eat healthy so that you stay healthy. Your diet should consist of proper quantities of vitamins, minerals and other supplements to prevent the break out of acne. Fresh fruits, vegetables, juices are the best to prevent acne flare-ups.
Cosmetics:
Anything that blocks and clogs the pores leading to skin irritation has enough potential to contribute to acne growth. You should use oil- free or non -comedogenic cosmetics. Shiny facial colors contain mica that clogs pores and causes skin irritations. Coal tar, derivatives, heavy cream and carmine are some other ingredients that irritate the skin leading to acne growth. Lip-glosses that are shinier contain comedogenic elements that clog pores to a large extent. So glosses that are matte finish are much better in this regard. Eye creams contain large quantities of moisturizers than normal creams and they clog pores around the eyes.
Hygiene:
Harsh chemicals on skin, over washing and scrubbing cause irritation. Oil secretion is increased if the face is rubbed and cleaned too often. This can lead to acne production. Gentle exfoliation is good for the skin. Alcohol products should be avoided at all costs.
These are some of the essential things that you have to keep in mind to steer clear of acne-ridden skin.
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Eye is unique and very precious organ. It is considered as window of the soul. We can enjoy and viewed the whole world only with this organ. There are many eye ailments which affect this organ and one can loss the eye sight also. Therefore many ophthalmic drug delivery systems are available. These are classified as conventional and newer drug delivery systems.Most commonly available ophthalmic preparations are eye drops and ointments. But these preparations when instilled into the cul-de-sac are rapidly drained away from the ocular cavity due to tear flow and lacrimal nasal drainage. Only a small amount is available for its therapeutic effect resulting in frequent dosing1. Thus inefficient drug delivery into the eye occurs due to rapid tear turn over, lacrimal. drainage and drug dilution by tears2.
Topical administration for ocular therapeutics is ideal because of smaller doses required compared to the systemic use, its rapid onset of action and freedom from systemic toxicity Topically applied ocular drugs have to reach the inner parts of the eye and transcorneal penetration is believed to be the major route for drug absorption. Corneal absorption is much slower process than elimination. For many drugs K loss (First order elimination rate) is approximately 0.5-0.7/min and K absorption (First order absorption rate) is about 0.001/min. The sum of these two rate constants control the fraction of the applied dose absorbed into the eye3. So the ocular bioavailability can be increased by decreasing K Ioss or by increasing K absorption. The former can be achieved by modifying the ocular dosage forms and the latter by formulating ocular dosage forms containing lipophilic prodrugs or by adding penetration enhancers. Therefore to optimize topical ocular drug delivery system prolonged contact time with the corneal surface and better penetration through cornea is necessary4.
A considerable amount of effort has been made in ophthalmic drug delivery since 1970’s. The two main approqches attempted are improvement in bioavailability and controlled release drug delivery.
ENHANCEMENT IN BIOAVAILABILITY
Topical bioavailability can be improved by maximizing precorneal drug absorption and minimizing precorneal drug loss.
1. Viscosity improver:
In order to prolong precorneal residence time and to improve bioavailability attempts were made to increase the viscosity of the formulation. The viscosity enhancers used were hydrophilic polymers such as cellulose, polyalcohol and polyacrylic acid. Sodium carboxy methyl cellulose is one of the most important mucoadhesion polymers having mono adhosive strength5. The effects of polyacrylic acid and polyacrylamide based hydrogels are tested on miotic response of pilocarpine. Carbomer were used in liquid and semisolid formulations as suspending or viscosity increasing agents. Formulations including creams, gels and ointments were used as ophthalmic products6. Polycarbophil is water insoluble cross linked polyacrylic acid helps in the retention of the drug delivery system in the eye7 due to the formation of hydrogel bonds and mucoadhesive strength. Hyaluronic acid offers a biocompatible and biodegradable matrix for fabrication of ocular sustained release dosage form- Dosage forms based on the benzyl esters of hyaluronic acid were used for ophthalmic sustained release of methyl prednisolone. Films and microspheres were also prepared from hyaluronic acid. Polysaccharide such as xanthan gum was found to increase the viscosity8. Today, hydrophilic polymers continue to be used in formulation of ophthatmic products Outs the” lunotions are mere for patient comfort and for bioadhesion rather than viscosity enhancement. Viscosity vehicles increases the contact time and no marked sustaining effect is seen.
2. Gels :
Gel formation is an extreme case of viscosity enhancement through the use of viscosity enhancers. So the dosing frequency can be decreased to once a day9. Cellulose acetate phthalate dispersion constituted a micro-reservoir system of high viscosity. Poloxamer 407 is used as an ophthalmic vehicle for pilocarpine delivery and found that the gel formation enhances the activity of pilocarpine10. Timolol maleate form thermogelling drug delivery system composed of cellulose ether ethylhydroxylethylcellulose11. The effect of flurbiprofen a non steroidal anti inflammatory, formulated in carbopol 940 and pluronic F 127 hydrogels were compared in ocular hypertension. Gelrite is a polysaccharide (gellen gum), which forms a clear gel in the presence of mono or divalent cation. The high viscosity of the gel, however, results in blurring of vision and malted eyelids which substantially reduce patient acceptability. Sterilization is another drawback for large-scale production,
3. Penetration enhancers:
They act by increasing corneal uptake by modifying the integrity of comeal epithelium. Chelating agents, preservatives, surfactants and bile salts were studied as possible penetration enhances. But the effort was diminished due to the local toxicity associated with enhancers12. Penetration enhancers have also been reported to reduce the drop size of conventional ophthalmic solutions especially if they do not elicit local irritation.
4. Prodrugs:
Prodrugs enhance comeal drug permeability through modification of the hydrophilic or lipophilicity of the drug13. The method includes modification of chemical structure of the drug molecule, thus making it selective, site specific and a safe ocular drug delivery system. Drugs with increased penetrability through prodrug formulations are-epinehrine13, phenylephrine, timolol, pilocarpine14 and albuterol.
5. Cyclodextrins:
Cyclodextrins act as carriers by keeping the hydrophobic drug molecules in solution and delivering them to the surface of the biological membrane, where the relatively lipophilic membrane has a much lower affinity for the hydrophilic eyclodextrin molecules WO therefore they remain in the aqueous vehicle system. Optimum bioavailability can be achieved when just enough cyclodextrin (
6. Bioadhesive polymers:
The bioadhesive polymers16 adhere to the mucin coat covering the conjunctiva and the comeal surfaces of the eye, thus prolonging the residence time of a drug in the conjunctival sac. These polymers can be neutral, synthetic or semi synthetic. Polyacrylic acid, polycarbophil and hyaluronic acid are synthetic polymers commonly used. Chitosan is a bioadhesive vehicle suitable for ophthalmic formulation since it exhibits general biological properties such as biodegradability, nontoxicity and biocompatibility. Due its positive charge at neutral pH and ionic interaction with the negative charges of sialic acid occurs. Xanthan and carrageenan are also described as bioadhesive polysaccharides17.
ENHANCEMENT IN CONTROLLED DRUG-DELIVERY
It is realized that the preferred system of ophthalmic delivery would provide improved bioavailability, site-specific delivery and with continuous drug release. So achievements have been made in the following areas:
1. In situ forming gels:
The progress has been made in gel technology lip the development of droppiable gel. They are liquid uponjnstillation and undergo phase transition in the ocular cul-de-sac to form visco-elastic gel and this provides a response to environmental changes18. Three methods have been employed to cause phase transition in the eye surface. These are change in pH, change in temperature and ion activation.
1. pH:
In this method gelling of the solution is triggered by a change in the pH. CAP latex cross linked polyacrylic acid and derivatives such as carbomers are used. They are low viscosity polymeric dispersion in water which undergoes spontaneous coagulation and gelation after instillafion in the conjunctival cul-de-sac19.
3. Temperature:
In this method gelling of the solution is triggered by change in the temperature. Sustained drug delivery can be achieved by the use of a polymer that changes from solution to gel at the temperature of the eye. But disadvantage of this is characterized by high polymer concentration (25% Poloxamers) 20. Methyl cellulose and smart hydrogels are other examples.
4. Ionic strength:
In this method gelling of the solution Instilled Is triggered by change In the Ionic strength. Example Is Gelrite. Gelrite is a polysaccharide, low acetyl gellan gum, which forms a clear gel in the presence of mono or divalent cations. The concentration of sodium in human tears is 2.6 g/l is particularly suitable to cause gelation of the material when topically installed into the conjunctival sac.
5. Oil in water emulsions:
Phospholipids and pluronics were used as the emulsifiers. Antioxidants were added to improve their shelf-life. The intra-ocular pressure reducing effect of a single, topically administered dose of a pilocarpine emulsion lasted for 29 h in rabbits compared to generic pilocarpine solution which lasted only for 5 h21. Oil in water emulsion is useful for delivery of Water insoluble drugs, which is solubilised in the internal oil phase.
6. Colloidal part Iles:
The potential use of polymeric colloidal particles as ophthalmic drug delivery systems started in late 1970’s.The first two systems studied in this area were pilocarpine cellulose acetate hydrogen phthalate latex systems and piloplex. But both the system could not enter commercial development because of various issues, like local toxicity, non-biodegradable polymer and large scale sterilization.
7. Liposomes :
The use of liposomes as a topically administered ocular drug delivery system began in the early stage of research into ophthalmic drug delivery. But the results were favorable for lipophilic drugs and not for-hydrophilic drugs. It was concluded that liposomes must be suitable for ocular drug delivery, provided, they had an affinity for, and were able to bind to, ocular surfaces, and release contents at optimal rates22. Positively charged liposomes have a greater affinity, to increase both precorneal drug retention and drug bioavailability .The addition of stearylamine to a liposomal preparation enhanced the corneal absorption of dexamethyl valerate. The corneal epithelium is thinly coated with negatively charged mucin to which the positive surface charge of the liposome may absorb more strongly. Coating with bioadhesive polymers to liposomes, prolong the precomea retention of liposomes. Carbopol 1342-coated pilocarpine23 containing liposomes were shown to produce a longer duration of action. Liposomal preparation of acetazolamide24, hydrocortisone25 and tropicamide26 has been reported. Coating the lipueme with bioadhesive polymat Ilka carbopal increased the corneal retention followed by sustained action Cyclosporin applied topically to the eye in the olive oil crops in a liposome encapsulated form and in a cellophane shield showed slow releasing property.
8. Nanoparticles:
Nanoparticles provide sustained release-and prolonged therapeutic activity when retained in the cul-de-sac after topical administration and the entrapped drug must be released from the particles at an appropriate rate. To enhance particle retention, it is desirable to fabricate the particles with bioadhesive materials. Biodegradation is also a highly desirable property for the fabrication of nanoparticles. Most commonly used polymers are venous poly (alkyl cyanoacrylates), poly S-caprolactone and polylactic-co-glycolic acid, which undergo hydrolysis in tears. Coating of nanoparticles with bioadhesive polymers improves the bioavailability. Chitosan coated nanocapsules improve the bioavailability27. Nanoparticles as an ophthalmic drug delivery have been demonstrated for both hydrophilic and hydrophobic drugs28-29.
9. Miarcipartlauldles:
They are drug containing, micron sized polymeric particles suspended in a liquid medium. Drugs can be physically dispersed in the polymer backbone30. The drug is released in cul-de-sac through diffusion, chemical reaction, and polymer degradation and micro particles are larger than nanoparticles. Acyclovir loaded chitosan microspheres31 and Pilocarpine-loaded albumin or gelatin microspheres32 are available. Microparticulate technology has the advantage of better patient acceptability, since they can be topically administered as an eye drop33. But the manufacture and control of large scale manufacturing of sterile micro particulates is very challenging and expensive.
10. Inserts:
Solid inserts were introduced into the market 50 years ago. The first solid insert was described in 1948 in British Pharmacopoeia. It was an atropine containing gelatin wafer and in 1980’s numerous systems were developed using various polymora and different drug release principles for controlled drug release.
Insoluble inserts are polymeric systems into which the drug is incorporated as a solution or dispersion21. Ophthalmic inserts (ocuserts) have been reported using alginate salts, PVP, modified collagen and HPC, Ocufit is a silicone elastomer based matrix that allows for the controlled release of an active ingredient over, a period of at least 2 weeks22. Osmotically controlled inserts have also been described, where release is by diffusion and osmotically controlled4.
Soluble inserts consists of all monolytic polymeric devices that at the end of their release, the device dissolve or erode. Soluble ophthalmic drug inserts is a soluble copolymer of acrylarnide, N-vinyl pyrrolidone and ethyl acrylate. It is a sterile thin film or wafer of oval shape. The system soften in 10-15 sec after introduction in to the upper conjuctivall sac, gradually dissolves within 1 h, while releasing the drug. A soluble insert containing gentamycin sulphate and dexamethasone phosphate has been developed Pilocarpine Insert for glaucoma is also reported. But these systems have the drawback that that blur vision while the polymer is dissolving. Water soluble bioadhesive component in its formulation has been developed to decrease the risk of expulsion and ensure prolonged residence in the eye, combined with controlled drug release. They are bioadhesive ophthalmic drug inserts. A system based on gentamycin obtained by extrusion of a mixture of polymers, showing a release timer of about 72 h has been reported. Due to difficulty with self-insertion, foreign body sensation, only few insert products are listed and pharmaceutical manufacturers are not actively developing inserts for commercialization.
11. Implantable systems:
The poly lactic acid and its copolymers with glycolic acid have been used extensively as implants. An ocular implant for delivering ganciclovir for the treatment of cytomegalovirus has also been developed24. This delivers drug directly to the retina for over 5 months. These systems are less popular as they require minor surgery.
12. Minidisc:
Minidisc is a controlled release monolithic matrix type device consisting of a contoured disc with a convex front and a concave back surface26. The principle component is A (1) bis (4-methacryloxybutyl)-polydimethyI siloxane. They can be made hydrophilic and hydrophobic to permit extended release of bath water soluble and water insoluble drugs.
13. Soft contact lenses:
The most widely used Material is poly-2-hydrosyethylmethacrylate. Its copolymers with PVP are used both to correct eyesight and hold and deliver drugs. Controlled release can be obtained by binding the active ingredient via biodegradable covalent linkages31.
14. Niosomes:
Niosomes are reported as successful ophthalmic carriers. Discoidal niosomes dscomes of timolol maleate have been reported to be promising systems for the controlled ocular administration of water soluble drugs20. The disc shape provides for a better fit in the cul-de-sac of the eye and then Large Size may prevent release their drainage into the systemic pool.
15. Pharmacosomes:
They are the vesicles formed by the amphiphilic drugs. Any drug possessing a free carboxyl group or an active hydrogen atom (-OH, -NH2) can be esterifies to the hydroxyl group of a lipid molecule, thus generating an amphiphilic prodrug. These are converted to pharmacosomes on dilution with water. They show greater stability, facilitated transport across the cornea and a controlled release profile16.
16. Collagen shields:
They are manufactured from porcine scleral tissue, which bears a collagen composition similar to that of human cornea. They are hydrated before being placed on the eye and the drug is loaded with the collagen shield simply by soaking it in the drug solution. They provide a layer of collagen solution that lubricates the eye. Collagen shields presoaked in tobramycin were used to treat Pseudomonas aeruginosa infected cornea excoriation28. But shield are not fully transparent and thus reduce visual activity. But they are appropriate delivery systems for both hydrophilic and hydrophobic drugs with poor penetration properties.
RECENT ADVANCES
New ophthalmic delivery system includes ocular inserts, collagen shields, ocular films, disposable contact lens and other Novel drug delivery systems like hiosomes20 and nanoparticles29. Newer trend is a combination of drug delivery technologies for improving the therapeutic response of a non efficacious drug. This can give a superior dosage forms for topical ophthalmic application.
SUMMARY
Among these drug delivery systems, only few products have been, commercialized. An ideal system should have effective drug concentration at the target tissue for a tended period of time with minimum systemic effect. Patient acceptance is very important for the design of any comfortable ophthalmic drug delivery system. Major Improvements are required in each system like improvement in sustained drug release, large scale manufacturing and stability. Combination of drug delivery systems could open a new directive for improving the therapeutic response of a non-efficacious system. They can overcome the limitations and combine the advantages of different systems.
REFERENCES
1. Aggarwal, D. and Kaur, I.P. Int. J. Pharm., 2005, 290, 155.
2. Bharath, C. and Hiremath. S-R., Pharmazie, 1999, 51, 55.
3. Calvo, P., Vila-Jato, L. and Alanso, M.J.. Int. J. Pharm., 1997 153, 41.
11. Kaur, I.P. and Smitha. R., Drug Develop. Ind. Pharm., 2002 28. 353.
12. Keistea, J.C., Cooper, E.R., Missel, P.J., Long, J.C. and Hager, D.F. J. Pharm. Sci, 1991, 80, 50.
13. Khopade, A.J. and Jain, N.K., Pharmazie, 19%. 50, 812.
14. Kumar, S., Haglund, B.O. and Himmelstein, K.J., J. Ocul. Pharmcol., 1994,10,47.
15. Kurz, D. and Ciullla, T.A., Ophthalmic Clin. North. Amer.. 2002,15.405.
16. Latorre F. and Nicolal, A.P., Drugs Exp, Clin, Res.. 1998, 24, 153.
17. Lee, V.H.L. and Robinson, J.R., J. Ocul. Pharmacol., 1986, 2, 67.
18. Lin. H.R. and Sung. K.C., J. Contol. release, 2000, 69, 379.
19. lnduPal. K. and Meenakshi, K., Drug Develop. Ind. Pharm., 2002, 473.
20. Marshall. W.S. and Klyee, S.D., J. Membrane Biol., 1983, 73, 275.
21. Meseuger, G., Gumy, R., Buri, P., Rozier, A. and Plazonnet, B., Int. J. Pharm., 1993, 95, 229.
22. Middleton, D.L, Leung, S.H.S. and Robinson, J.R., In; Lenaerts,V and Gummy, R., Eds., Bioadhesive Drug Delivery Systems, CRC Press, Boca Raton., 1990. 203.
23. Monem, A.S, Ali, FM. and Ismail. M W . Int. J. Pherm., 2000 198, 20.
24. Nagarsenker, M.S., Londhe, VY. and Nadkarni. G D. Int. J. Pharm., 1999, 190, 63.
25. Rathore K.S., Nema R.K., “Management of Glaucoma: a review” International Journal of Pharm Tech Research, Vol.1, No.3, pp, July-Sept. 2009.
26. Rathore K.S., nema R.K., “An Insight into Ophthalmic Drug Delivery System”, published online at www.ijpsdr.com. June-Aug.2009 issue
27. Rathore K.S., Nema R.K., “Review on Ocular inserts” International Journal of Pharm tech Research, Vol.1, No.2, pp 164-169, April-June 2009.
28. Rathore K.S., Nema R.K., “Formulation and evaluation of ophthalmic films for timolol maleate” planta indica, vol.no.4, October-December, 2008, p49-50.
29. Simamora, P., Nadkarni, S.R., Lee, Y.C. and Yalkowsky, S.H., Int. J. Pharm., 1998, 170, 209.
30. Urtti, A., RouhWnen, H., Kaila, T. and Saano. V., Pharm. Res., 1994.11,1278.
31. Wei, G., Xu, H., Ding, PT, U. S.M. and Zheng. J.M., J. Control. Release, 2002, 83, 65.
32. Yasmin. S. and Asgar. A.. Pharma Times, 1998. 13.
33. Zimmer, A.K., Chetoni, R. Saettone, M.P. Zerbe, H. and Kreuter, J., J. Control. Release, 1995. 33, 31.
About the Author
Kamal Singh Rathore, reader, BN Girls College of Pharmacy, Udaipur *E-mail: kamalsrathore@yahoo.com;kamalsrathore@gmail.com Mobile: +919828325713
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Tips For Keratosis Pilaris Skin Relief With Natural Treatments
Keratosis Pilaris (KP) is very common and about 40% of the population suffers from this inherited condition. While most people aren’t aware of this skin condition and categorize it as “chicken skin” or “goose bumps”, others are truly bothered by KP.
For those who are bothered by the condition and seek skin relief and treatment to smooth those skin bumps, there are several treatments and home remedies that can be of great help. Dryness and the sand-paper-feel to the touch seem to be main concerns when dealing with this common condition.
Home Remedies
It’s always good to implement some Skin Care routines that can help to alleviate the symptoms. These are just a few known home remedies that are inexpensive yet effective for KP:
Olive Oil: If you don’t mind smelling like a Greek salad every once and a while, try using a bit of olive oil on the areas you want to treat. Keratosis pilaris is categorized as a Dry Skin condition, so providing any extra moisture will help your skin. This will also help to improve the skin bumps feel to the touch.
Sugar Scrub: Take some regular sugar with some drops of olive oil or water and use it to exfoliate your skin. This will help to gently remove dead skin cells to improve texture.
Natural Treatments
If you rather use a treatment to control the condition, we can highly recommend products that contain a natural form of Salicylic Acid. If you’ve heard that salicylic acid have a bad rep, it’s because they are talking about the synthetic form. Natural, like salicylic acid from the willow bark, is gentler on Sensitive Skin types and it’s therefore a lot better than the chemical variations.
Another ingredient that seem a bit strange to most people is snail secretion from the common garden snail. Believe it or not, this ingredient is found in many skin care creams to trigger skin renewal. This ingredient has the ability to penetrate the skin and deal with the problem from its root, which is what you want to look for to control Keratosis Pilaris.
Keratosis Pilaris can be a really troublesome condition if you are affected by itchy skin bumps on your upper arms, thighs or buttocks. To control the problem, you need to implement a skin care routine. The basics to control a problem related to dry skin is always to moisturize. With that said, finding a skin Care Cream that contain snail secretion in addition to salicylic acid is the best way to prevent keratosis pilaris skin from ever affecting your life.
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The health benefits of oil pulling are worth their weight in gold. You have already seen the basic oral benefits in regards to plaque reduction; however it does NOT stop there. Here are various other benefits that oil pulling has on your oral health:
Strengthens Teeth/gums
Prevents tooth decay
Prevents Decreases/Malodor
Repairs loose teeth
REVERSES Gingivitis
These are just SOME of the various oral health care benefits that Oil Pulling can have. The power of oil pulling however is not simply limited to oral care, here are some of the other health care issues Oil Pulling will cure/treat:
Sinus Problems
Constipation
Bronchitis
Menopause
Cancer
Chronic Diseases
As you can see, the benefits of Oil Pulling are unparalleled and should be done by everybody on a daily basis, you have absolutely nothing to lose! Lucky for you, oil pulling only involves one ingredient, OIL! There is ABSOLUTELY nothing else you need (I will show you where to purchase the oils for CHEAP). In addition, you are not limited to just one type of oil. Sesame, Olive, Sunflower, and Coconut oil can all be used, it is up to you. Also, ONE bottle of oil can last you MONTHS since you will be only using 1-2 tablespoons per day. I used to suffer from many chronic health problems. Unfortunately, cleanses did not really work for me no matter how many I tried. However, Oil Pulling was my saving grace and still is until this day I encourage you all to explore this with open minds. With only using 15-25 minutes of your time daily, you have nothing to lose!
About the Author
Oil Pulling Secrets
Risha Jain has been oil pulling for several years now and continues to do so till this day. She has recently started a website/blog devoted to the topic and has also recently completed an E-book which can also be found on the site. For information,help,tips, and discussions about oil pulling, visit her website at:
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Laser Surgery To Remove Scars
Most people would probably have scars which they want to remove for aesthetic or other reasons. Facial scars could be the in thing now if you have watched the Pirates of the Caribbean. Some even consider it a fashion statement. However, most people would probably like their facial scars to be removed.
There are many methods being used to remove scars and one of the most convenient methods would to remove scars by cosmetic laser surgery. However, we must first understand what scars are.
A scar is the body’s natural way of healing itself by replacing lost or damaged skin. Scars may occur for many reasons such as from surgery, injuries, cuts, infections or inflammation of body tissues. Scars can come with different appearances and forms like just being flat, lumpy, sunken, colored, itchy or even being painful. The look of a scar will depend on factors such as skin type, location on the body, the direction and type of the injury, age of the person and his/her nutrition.
Scars usually fade with the passing of time and many scars do not disappear completely. Cosmetics and make up can help to cover light unsightly scars. Some scars can be minimized or lightened by certain dermatological treatments.
Some of the techniques that help to remove or improve the scars are dermabrasion, chemical peels, collagen injections, cryosurgery, skin grafts, surgical scar revision, laser resurfacing, and autologous fat transfer just to name a few of the many methods.
The laser scar removal technique can reduce the appearance of keloid scars, hypertrophic scars, and atrophic scars. Unfortunately, people with darker skin may not be able to use laser scar removal. People who suffer from skin disorders such as psoriasis, cystic acne, and dermatitis may also not be able to undergo laser scar removal method. People who are on medication such as isotretinoin for acne must stop using the medication for at least half a year before they are able to undergo the laser treatment.
During laser scar removal, the laser is moved along the scar. This vaporizes or removes a layer of skin and exposes a more natural-looking skin, which heals over time to minimize scar appearance. There are several types of laser treatments and each has its own benefits.
The laser scar removal procedure is often performed under local anesthesia. Sometimes, general anesthesia may also used if treatment is made over a large area of the body. The laser surgery is usually performed from just a few minutes to an hour long or so depending on the patient’s condition and the methods used.
The patient’s recovery process can begin as early as three to four days after the laser treatment. Speed of skin regeneration will largely depend on the type of laser surgery method used, personal healing ability and adherence to medical instructions.
The most common side effect of laser scar removal surgery is skin hyper pigmentation. This condition can be made worse through sun exposure. Infection or allergic reactions are also possible side effects.
Do consult with your dermatologist to get an informed opinion to see if you are suitable for laser scar removal surgery.
ScarAway helps restore raised and discolored scars to a more natural color and texture, using the same technology trusted by burn centers and plastic surgeons. Using ScarAway on newly healed wounds helps prevent the formation of unsightly scars. Even scars that are years old from burns, surgical procedures and injuries show significant improvement with ScarAway. Previously available only to medica…
The Solution for Scars™With Patented Silon® TechnologySignificantly improves the appearance of existing scarsHelps prevent the formation of new scarsProfessional GradeTechnology used by Burn Centers and Plastic SurgeonsLatex FreeClinically proven technology used by Plastic Surgeons, Hospitals, and Burn Centers around the world!ScarAway Professional grade silicone scar sheets are indicated fo…
Cica-Care Gel Sheet is a patented technically advanced form of silicone gel sheet for scar care Widely used by hospitals, dermatologists, and surgeons for the management of hypertrophic and keloid scars. The Cica-Care adhesive gel sheet is soft, comfortable and simple to apply. It can be cut to size to fit most scars.
Durable and reusable, it can be used day or night. The skin contact side of Cic…
This digital document is an article from Skin & Allergy News, published by International Medical News Group on September 1, 2002. The length of the article is 468 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser.Citation …
This digital document is an article from Skin & Allergy News, published by Thomson Gale on July 1, 2006. The length of the article is 964 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser.Citation DetailsTitle: PDT and pre…
This digital document is an article from Internal Medicine News, published by International Medical News Group on September 1, 2008. The length of the article is 731 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available immediately after purchase. You can view it with any web browser.Citation DetailsTitle: Shave reduction p…
KELOID TUTORIAL DALLAS: PLASTIC SURGERY WITH RADIATION THER
Your annual report is the single most important document your company produces – and it’s most powerful public relations and marketing tool. A thoughtfully designed annual communicates corporate culture and values, recruits new talent, builds brand recognition, boosts corporate image and offers people a glimpse at the organization behind the numbers.
Dollars and Sense
In studies conducted by the Ernst & Young Center for Business Innovation diverse investors consistently placed a premium on non-financial criteria. Attributes such as branding, strategy execution, management credibility, innovation, ability to attract and retain talented people, and R&D ranked high among those polled. The study determined that fully one third of a company’s stock share price is attributable to such non-financial factors. Clearly these types of assets are crucial to success – communicating them effectively in your annual can have tremendous impact on shareholder confidence and investor perception.
Maximize the Message
Your annual report will leave a lasting impression. Everything must be perfect. Navigating production obstacles and emerging with a compelling annual requires finesse. Minimize the headaches and maximize your message by keeping these tips in mind:
1. Communicate excellence through design. The quality of concept, layout, printing and bindery, paper, graphics, photography, illustration and copywriting are all reflections of your organization. Skimping or cutting corners in these areas could convey cheapness, inefficiency and an overall inferiority that reflects poorly on you and your products and services. Collaborate with experienced designers who know how to produce high caliber work and who are sensitive to the nuance of layout and design spanning a 100+ page document.
2. Eschew pedantry and esoteric vocational patois. That is to say, don’t use a lot of technical mumbo jumbo that people outside your industry won’t understand. Be clear and concise – speak to your audience not at them. Your annual is an opportunity to educate people about what you do, how you do it, who you do it for, and why. Straightforward, engaging copy will get the message across and create momentum that carries readers from page to page.
3. Flaunt your assets. Financial statements tell people how you did last year, but investors also want to know that you’re prepared for tomorrow. Non-financial performance information lets them know if you’re poised for growth and capable of weathering financial storms. Emphasizing advantages such as comprehensive branding, or skilled management and labor retention rates reassures investors you have what it takes to keep moving forward.
4. Look to the future. Discuss your intent for the coming year – even the next five, 10,or 20 years. Outline your objectives and your plan to meet them. If, for example, acquisition is required to boost revenue, explain the risks associated with such a move – expense of integration and timeframe for return.
5. Go digital. Making your annual report available via the company web site is cost- effective and eco-friendly. A digital version of your report is an excellent supplement to the printed book, but not a replacement – printed reports are still a must.
6. Provide enough time to get the job done right. Timeframes vary between SEC rules the NYSE, and AMEX, but it’s never too early to start thinking about next year’s report.
About the Author
Ken Peters is the owner and Creative Director of nationally acclaimed Nocturnal Graphic Design Studio LLC, a Phoenix-based strategic design firm specializing in brand development and brand launch. To view samples from Nocturnal’s portfolio, visit www.nocturnaldesign.com.
This revolutional formula helps your skin balance its own natural oil levels, so your complexion looks smooth and even – not shiny. Helps remove oil and other impurities that may cause pores to clog and hels preven makeup from streaking throughout the day….
Hugh Sigma Brush Give away, Mac Haul Thank you Shellz
The 2009 Queensland oil spill occurred on March 11, 2009 off the coast of southeast Queensland. On that fateful night when Cyclone Hamish battered the coast of Australia’s northern state, MV Pacific Adventurer spilled 230 tons of fuel oil, 30 tons of other fuel, and 620 tons of ammonium nitrate into the Coral Sea, north of Moreton Bay, changing the face of the much-famed Gold Coast.
Unsecured cargo on the ship dislodged from the deck and damaged other cargo onboard, causing the spillage. Sixty kilometers of pristine coastline areas, including Sunshine Coast, Moreton Bay, and Bribie Island were badly affected by the spill. Oil spill cleanup operations have cost the government so much in terms of money. It is widely believed that 31 containers with ammonium nitrate are still present somewhere in the Coral Sea floor; if it disperses into the ocean it might cause widespread algal blooms.
What is the bearing on the ecosystem
The oil spilled in one of Australia’s worst ever oil spill disasters is highly toxic heavy-grade bunker oil. Bunker oil is not easy to get rid of and a thick sludge remains even after the volatile part of the oil has evaporated. Products from Oil Gone Easy help in removal of such spills caused by oil spill disasters in an eco-friendly manner.
Oil spill effects on the ecosystem can be disastrous and wildlife coming into direct contact with the oil will be severely affected. Inhaling, ingesting, and absorbing oil are dangerous as well. Once it enters the food chain, the entire cycle can get contaminated, ranging from the smallest plankton to human beings. Depending on the intensity and level of exposure to oil vapor, it might lead to cancer. They can also damage various parts of the body, including blood, kidney, liver, skin, central nervous system, and parts of the eye.
The Amazing Scum-Ball (2-Pack) for Pools & Spas Purges Oils & Lotions, Prevents Scum Lines & Foaming. The Scum-Ball is a simple, inexpensive pool & spa water maintenance item that absorbs 40x its weight in body oils, lotions & swimmer waste. to prevent the formation of scum lines at the water’s edge, and reduce foaming. Simply drop it in your pool or spa water, and it goes to work – automatically….
For decades, people have sought a convenient solution to the dilemma of determining how to dispose of leftover cooking grease. Pouring it down the drain can clog pipes, while dumping it outside is bad for the environment. And most other methods are usually either messy or unsanitary. Finally, an answer has emerged. Made from disposable, biodegradable, FDA-approved material, AbsorbEase can be place…
Ultra light lotion that absorbs excess oils on skin surface instantly Mattes out shine & provides a smooth healthy finish Salicylic Acid clears congested follicles to reduce future breakouts Regulated sebum production & soothes irritation Leaves skin clear pure & refreshed Contains no artificial fragrance or color Perfect for acne-prone skinProduct Line: Dermalogica – Day CareProduct Size: 1…
Great way to keep spills under control. Large 4 1/2 gallon pail of absorbent material. Simply scoop out absorbent and sprinkle it on spill.
Wait for absorption to occur.
When fully adsorbed scoop up waste for proper disposal.
May be land filled in accordance with local, state, and federal regulations.
If any residue remains on the floor, then reapply more absorbent and stir with a broom until all…
INDICATIONS: Baby Magic creamy baby oil, soft baby scent is an enriched creamy oil wash with Aloe and Vitamins to help soften and seal in the natural moisture of the baby’s skin. It will leave your baby smelling wonderful….
The Abzorb Oil mat is a super-absorbent solution for your garage needs. No more expensive degreasers, mess and stains. The disposable Abzorb mat will absorb oil and melting snow off your car — and that means less mess tracked into your home. Best of all, it prevents permanent damage caused by oil, rust and water stains. The Abzorb mat also: The Abzorb mat is approxiamately 1/8th inch thick. So …
The Abzorb Oil mat is a super-absorbent solution for your garage needs. No more expensive degreasers, mess and stains. The disposable Abzorb mat will absorb oil and melting snow off your car — and that means less mess tracked into your home. Best of all, it prevents permanent damage caused by oil, rust and water stains. The Abzorb mat also: The Abzorb mat is approxiamately 1/8th inch thick. So …
The Abzorb Oil mat is a super-absorbent solution for your garage needs. No more expensive degreasers, mess and stains. The disposable Abzorb mat will absorb oil and melting snow off your car — and that means less mess tracked into your home. Best of all, it prevents permanent damage caused by oil, rust and water stains. The Abzorb mat also: The Abzorb mat is approxiamately 1/8th inch thick. So …
Hair loss is a normal process that involves loss of around 50 to 100 scalp hairs everyday. When hair loss starts exceeding this limit then you should start worrying about that hair loss. Baldness is a condition that results when the hair regeneration is, at an extremely slow rate compared to the hair loss rate.
Hair loss is caused by many reasons most of the time the reason is Androgenetic Alopecia also known as Male or female pattern hair loss. Telogen Effluvium is the type of hair loss that is caused from stress. The stress causes the hair in the resting phase to fall out without providing any replacement of the hair, thus resulting in baldness.
Anagen effluvium occurs due to chemicals, Chemotherapy is one of the medical treatments that can cause it. Chemotherapy is used to kill cancer causing cells but besides killing these cells as a side effect it also kills the hair follicles. This results in hair loss which would automatically stop as soon as the chemotherapy stops. The hair loss in this case is temporary.
Hair loss treatment can be quite challenging as most of the treatments are not effective and have side effects. New Generation Hair Loss Solutions are different in this respect they are effective and have no side effects. New Generation also provides hair care products along with their hair loss remedy. Once a New Generation Customer always a New Gen Customer.
The New Generation hair loss prevention products include a hair loss shampoo, a conditioner, an overnight formula and a Dietary Supplement. All these products provide you with a comprehensive treatment that treats All Your hair loss problems efficiently. These incredible products are based on the renowned hair growth formula of Dr. Ilona Schreck-Purola, M.D of University of Helsinki and are backed by California Pacific Research. Polysorbate 60 is one of the main ingredients in this amazing overnight formula which is responsible for the wonderful results that New Generation products provide.
New Generations hair loss products provide the user with a healthy environment for thicker fuller healthier hair by deep cleaning, increasing scalp circulation, energizing and revitalizing the scalp. Visit the site www.newgen2000.com and order your set of these incredible products today why wait any longer to look great.
Step two of our Proactiv® Solution daily essentials, this refreshing, alcohol-free toner helps balance skin tone and remove dead skin cells to reveal the vital, radiant skin beneath.
Size: 4 oz.
Benefits:
Our special formulation balances skin’s natural acids
Our rich, deep-cleansing mask is formulated with sulfur, a proven acne-fighting ingredient that reaches deep into pores where blemishes begin. Cool, soothing Kaolin, (also known as China Clay) helps absorb excess surface oils while our special sulfur formula soothes inflammation and refines skin tone and texture.
Size: 2.5 oz….
When you have trouble getting a good nightâs rest, especially for an extended period of time, the tiredness can impact every part of your life. Physically, you might notice a decrease in productivity and daily activities. Emotionally, you may experience relationship problems or a change in your personality. Mentally, a chronic sleep problem can lead to feelings of stress and anxiety.With Sle…
Jane Carter Solution review (conditioner, leave in, condition & sculpt) Day 16 “No Cone” Challenge
Are Shea Butter Skin Care Acne Treatments Really Effective?
Some acne products claim that shea butter as an active ingredient; one that is supposed to help eliminate acne. What exactly is shea butter, and how does it benefit a person’s skin? Do shea butter skin Care Acne products really work to eliminate acne? Read on as I discuss this particular subject that many are concerned with.
Shea butter is derived from a nut that originates from the Savannah Region of Africa. Many claim that shea butter is good for the treatment of skin ailments like psoriasis, eczema and acne; this generally held belief has lead to the production of many shea butter skin care acne products which I’m sure you have seen anywhere from your local supermarket to your high end health food shop.
One question many face is whether products containing shea butter are good for acne- Prone Skin, considering the fact that the term butter indicates an oily or greasy substance. Since acne results from Excess Oil and the presence of dirt and bacteria on a person’s skin, the question about the effectiveness of shea butter-based skin care acne products is legitimate, an analysis would be required to determine just how effective shea butter really is.
At this point it’s best to analyze the effectiveness of shea butter in treating acne by scrutinizing the effects that this substance has on a person’s skin. Shea butter helps treat scars and burns, and also has been known to help prevent skin rashes. This may be the reason why shea butter is considered an ideal substance for use in Acne Treatment programs despite its greasy moniker. This substance, which is included in beauty products aimed at treating conditions such as acne, blemishes, dandruff, Dry Skin and rashes, is used because of the versatility of its application.
Shea butter skin care acne products include soaps, ointments, creams and oils. Since oil is not advisable for those suffering from acne, you may need to ask your dermatologist about this before you use oils or creams made with shea butter. While shea butter skin care acne products may claim that the substance itself is beneficial to people with acne, the form it comes in may not benefit everyone. If you experiment with a shea butter skin care acne product that your doctor does not know about or does not recommend,
you might find yourself having more skin problems that need more remedies; basically, you’re back at square one in your fight against frequent acne.
About the Author
Garey Simmons has studied health for 2 years to acquire a
perspective on the natural means of reversing Acne Skin issues. A Free
Exclusive Report Regarding Natural Skin Care can be downloaded at
this Skin
Care Site
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From queens to commoners, turmeric has been indispensable as a skin-care preparation and grooming aid for every woman. This is because 63% of the body functions are said to be controlled by the skin alone. VICCO has combined the goodness of TURMERIC which is said to prevent the penetration of ultra violet rays of the sun into the skin and thus maintains the original color of the pigment of the ski…
VICCO has combined the goodness of TURMERIC which is said to prevent the penetration of ultra violet rays of the sun into the skin and thus maintains the original colour of the pigment of the skin, with the richness of pure SANDALWOOD OIL which is supposed to be the most cooling element in Vicco Turmeric Cream. This luxurious cream vanishes into your skin and starts working its magic from within….
What it is:A unique, lightweight emulsion that relieves post-shave redness and stinging.What it is formulated to do:Instantly cool, hydrate, and soothe skin after shaving with this anti-inflammatory remedy. Special herbal extracts, key essential oils, and vitamins help to heal the skin, easing shaving irritation. Razor Burn Repair is most effective when applied immediately after shaving. It can be…
Scars / Scar Care / Dr. Blaine’s Complete ScarCare Treatment
Anti aging products can be found practically anywhere that cosmetics are sold. As people get older they sometimes begin to look at all the products offered as they race to combat the aging process. Everyone ages differently and while someone might not need anti aging products until their in there fifties, other people tend to look in their late twenties.
There are many products available that can cater to your entire body from your hands to your face/neck and even your entire body. That makes the idea of wrinkles seem like there in the past! Although many products claim to work, others may do nothing but moisturize the skin. It is important to know that products can work differently on everyone and that trying various ones might be the answer to fighting the aging process.
Yves Roches is a company that has been around for a long time. They have many different kinds of cosmetic products but they also have an anti-aging line. One of their popular products is the Bust Firming Cream. It is made with mangifera extract and rehydrating maple sap, it`s concentrated and features SPA. This cream is recommended for use every day and there are specific instructions on the packaging for exact use. Another product they offer is called `Anti aging body treatment `. It features ten botanical oils; it`s also scented and has a milky replenishing feel to it. This product can be used on the whole body; they also carry one for night time use and another for daytime, specifically for the neck and face.
Intense reconstruction body location and anti dryness in 24 hours is another product offered by Yves roches. It has over 30 oils and there is one for the eyes for night time application, a deep regenerating one and a day/night time cream. Lift effect age defying body lotion serum with Shiitake is a product that claims to provide stronger and more revitalized skin over long time use. There is also a similar product for anti-fatigue, a smooth eraser cream and serum, a duo toner pack, a serum with shiitake and a toner with shiitake.
Borba is another cosmetic company that also carries an anti-aging product line. They have an advanced aging custom control cleanser, hand cream, recovery cream, revere and tone cream, and a deep wrinkle repair. With all of the creams available there is sure to be one that fits your direct need and concern. They also carry a popular age defying aqua-less crystalline product that comes with packets. This product features the famous Acai berry and it is high in antioxidants and it has a bio-vitamin complex.
Ester Lauder is another very popular cosmetic company that has an anti-aging line. They offer a product called Perfectionist, it says that it can lift and firm and provide a wrinkle serum that offers great results. They also have an advanced night repair cream and a synchronized recovery complex cream and ultra firming cream lotion that is quite liked by many consumers.
You may seem baffled by all of the products available for the prevention of skin that looks aged. They key is to find one or two products and test them out for a few days or weeks. You can go by the recommendations of an expert or find the brands and products that are best selling. And keep in mind that everyone is different so one product might not work for two people.
About the Author
You can have access to articles about health in portuguese language from page Health
Roberto Sedycias works as IT consultant for Polomercantil br.
Duo Printer Stand This Duo Printer Stand features open knee space providing ample legroom, a top surface for monitor and CPU storage, pullout keyboard that includes a fabric covered foam wrist support, and a mouse tray that mounts on the left or right side. Complete with a privacy panel with openings for cable routing and four swivel casters (two locking) for mobility. Choose to add the optional …
Janson Beckett’s Certified Organic Cleansing and Toning Duo is formulated with nourishing organic ingredients. It restores radiance and youthfulness to the skin with the help of botanicals and vitamins. This duo perfectly preps the skin for your daily skin care regimen. Kit Includes: Certified Organic Cleansing Milk – This Certified Organic formula cleans deeper than common cleansers to flush dirt…
A rich day and night cream, S-ence delivers fresh glowing appearance for dull, dry and aging skin. MicroCollagen is re-enforced by Green Algae extract and a peptide. These active ingredients, in a highly penetrating base, simulate synthesis of collagen and gulcosaminogycans, diminishing wrinkles and replenishing the skin. S-ence cream contains phospholipids, the key ingredient in the maint…
Hey Everyone, Kyle here, I just want to thank you for checking out my site dedicated to healing acne. I think you’ll really enjoy my story and the information I have about clearing up your skin.